A novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development

The lymphatic vasculature plays important role in regulating fluid homeostasis, intestinal lipid absorption, and immune surveillance in humans. Malfunction of lymphatic vasculature leads to several human diseases. Understanding the fundamental mechanism in lymphatic vascular development not only expand our knowledge, but also provide a new therapeutic insight. Recently, Hippo-YAP/TAZ signaling pathway, a key mechanism of organ size and tissue homeostasis, has emerged as a critical player that regulate lymphatic specification, sprouting, and maturation. In this review, we discuss the mechanistic regulation and pathophysiological significant of Hippo pathway in lymphatic vascular development.

Automated summary

The lymphatic vasculature plays a critical role in regulating fluid balance, intestinal lipid absorption, and immune surveillance in the human body, while dysfunction can lead to various diseases. Understanding the mechanisms of lymphatic vascular development is important for expanding knowledge and providing new therapeutic perspectives. The Hippo-YAP/TAZ signaling pathway has emerged as a key player in regulating lymphatic specification and maturation.