Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 8, Issue 17, Pages 4871-4877Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo00701g
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Funding
- National Natural Science Foundation of China [21602078]
- Pearl River Talent Program of Guangdong Province (Youth top-notch talent) [2017GC010302]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515011743]
- Jinan University
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This study demonstrates a mild and general protocol for the photoredox initiated oxo-azolation of gem-difluoroalkenes, providing a facile access to synthetically useful azolated difluoroacetonarenes with potential applications in drug and functional materials development. The reaction tolerates a wide range of functional groups and involves a photoredox initiated, active oxygen participated single electron transfer pathway. Furthermore, the reaction solvent can be easily recovered and reused with the same efficiency.
A mild and general protocol for photoredox initiated oxo-azolation of gem-difluoroalkenes has been demonstrated. The reaction strategy offers a facile access to a series of synthetically useful azolated difluoroacetonarenes that may have significant applications in drug and functional materials development. The reaction also tolerates a wide range of functional groups for further manipulation. In addition, a preliminary mechanistic study indicated a photoredox initiated, active oxygen participated single electron transfer pathway for the reaction. Finally, the reaction solvent could be easily recovered and reused with the same reaction efficiency.
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