Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 17, Issue 10, Pages 2666-2682Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.59117
Keywords
Pancreatic cancer; Oncolytic viruses; Bacteria; Mycoplasma; Chemotherapy
Categories
Funding
- National Natural Science Foundation of China [81772555, 81802352, 81902428]
- National Science Foundation for Distinguished Young Scholars of China [81625016]
- Shanghai Sailing Program [19YF1409400, 20YF1409000]
- Shanghai Rising-Star Program [20QA1402100]
- Shanghai Anticancer Association Young Eagle Program [SACA-CY19A06]
- Clinical and Scientific Innovation Project of Shanghai Hospital Development Center [SHDC12018109, SHDC12019109]
- Scientific Innovation Project of Shanghai Education Committee [2019-01-07-00-07-E00057]
Ask authors/readers for more resources
This review discusses the influences of microorganisms on pancreatic cancer chemotherapy, highlighting the significant role of microorganisms in the occurrence and progression of pancreatic cancer, as well as their importance in modulating chemotherapy effects and predicting prognosis as biomarkers. Further studies are necessary to understand the mechanism underlying the interaction between microorganisms and pancreatic cancer.
Pancreatic cancer is a malignant tumor of the digestive system with a very high mortality rate. While gemcitabine-based chemotherapy is the predominant treatment for terminal pancreatic cancer, its therapeutic effect is not satisfactory. Recently, many studies have found that microorganisms not only play a consequential role in the occurrence and progression of pancreatic cancer but also modulate the effect of chemotherapy to some extent. Moreover, microorganisms may become an important biomarker for predicting pancreatic carcinogenesis and detecting the prognosis of pancreatic cancer. However, the existing experimental literature is not sufficient or convincing. Therefore, further exploration and experiments are imperative to understanding the mechanism underlying the interaction between microorganisms and pancreatic cancer. In this review, we primarily summarize and discuss the influences of oncolytic viruses and bacteria on pancreatic cancer chemotherapy because these are the two types of microorganisms that are most often studied. We focus on some potential methods specific to these two types of microorganisms that can be used to improve the efficacy of chemotherapy in pancreatic cancer therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available