Journal
MATERIALS CHEMISTRY FRONTIERS
Volume 5, Issue 16, Pages 6041-6051Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qm00490e
Keywords
-
Funding
- National Key Research and Development Program of China [2016YFE0133100]
- National Natural Science Foundation of China [31971322]
- Strategic Priority Research Program of Chinese Academy of Sciences [XDB36000000]
- Innovative Research Groups of the National Natural Science Foundation of China [11621505]
- Research and Development Project in Key Areas of Guangdong Province [2019B090917011]
Ask authors/readers for more resources
The nanocomposite GDY-hemin, with high peroxidase activity, effectively combats bacterial infections and demonstrates good biocompatibility.
Surgical site infections are the most common and serious concern in health care settings. Currently, systemic administration of prophylactic antibiotics or local disinfection treatment is prescribed after surgical procedures. However, prolonged use of antibiotics may pose adverse side effects, bacterial resistance and hospitalization costs. Recently, the use of nanomaterials with peroxidase enzyme-mimic activity has drawn higher consideration due to their high antibacterial potential and minimum biotoxicity. Hemin is a highly active molecule and also the active source of many biological enzymes, such as peroxidase, which could efficiently catalyze various biochemical reactions. However, the insolubility of hemin makes it easy for it to aggregate and lose its catalytic ability. Here, we designed a well-dispersed hemin/graphdiyne (GDY) nanocomposite (GDY-hemin) with high peroxidase activity. GDY-hemin can decompose hydrogen peroxide (H2O2) to generate highly-toxic hydroxyl radicals that impair bacterial cell membranes, ultimately leading to bacterial death in both in vitro and in vivo experiments. The results reveal that GDY-hemin has good biocompatibility and is suitable for wound infection treatment in vivo.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available