Journal
BIOMATERIALS SCIENCE
Volume 9, Issue 15, Pages 5144-5149Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1bm00275a
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Funding
- RCSI secondment award
- Canadian Institutes of Health Research (CIHR)
- Pennsylvania State University
- Science Foundation Ireland (SFI) [13/IA/1840]
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By rational design, block sequence controlled triblock copolypeptides with cysteine and tyrosine, as well as a lysine or glutamic acid center block, were developed. These copolypeptides contribute specific properties to hydrogels, making them extrusion printable and antimicrobial. Complex hydrogel structures with high shape retention were demonstrated through 3D printing, along with composition-dependent potent antimicrobial activity in contact-killing assays.
Through rational design, block sequence controlled triblock copolypeptides comprising cysteine and tyrosine as well as a lysine or glutamic acid central block are devised. In these copolypeptides, each block contributes a specific property to the hydrogels to render them extrusion printable and antimicrobial. Three-dimensional (3D) printing of complex hydrogel structures with high shape retention is demonstrated. Moreover, composition dependent potent antimicrobial activity in contact-killing assays is elucidated.
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