Journal
JOURNAL OF MEDICAL INVESTIGATION
Volume 68, Issue 1-2, Pages 189-191Publisher
UNIV TOKUSHIMA SCH MEDICINE
Keywords
congenital hypogonadotropic hypogonadism; coronary artery disease; diabetes mellitus; Kallmann syndrome; testosterone
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This case report describes a middle-aged man with congenital hypogonadotropic hypogonadism (HH) who had severe coronary artery disease complicated with metabolic disorders.
The patient with congenital hypogonadotropic hypogonadism (HH) shows low serum levels of androgen, which is a group of sex hormones including testosterone, caused by the decreased gonadotropin release in the hypothalamus. Recent reports showed androgens exert protective effects against insulin resistance or atherosclerotic diseases, such as diabetes mellitus or coronary artery disease. However, whether the juvenile hypogonadism affects the diabetes or cardiovascular disease is unclear. We report a case of a middle-aged man with congenital HH who had severe coronary artery disease complicated with metabolic disorders.
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