Journal
CHEMICAL SCIENCE
Volume 12, Issue 29, Pages 9885-9894Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1sc02069b
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Funding
- National Natural Science Foundation of China [21878087, 21908060]
- Innovation Program of Shanghai Municipal Education Commission [2019-01-07-00-02-E00060]
- Shuguang Program [18SG27]
- Fundamental Research Funds for the Central Universities
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Beta-galactosidase is an important biomarker for cell senescence and primary ovarian cancers. Advances in activatable probes for monitoring its activity include spectral characteristics, responsiveness regulation, and development from one-mode to dual-mode imaging.
beta-Galactosidase (beta-gal), a typical hydrolytic enzyme, is a vital biomarker for cell senescence and primary ovarian cancers. Developing precise and rapid methods to monitor beta-gal activity is crucial for early cancer diagnoses and biological research. Over the past decade, activatable optical probes have become a powerful tool for real-time tracking and in vivo visualization with high sensitivity and specificity. In this review, we summarize the latest advances in the design of beta-gal-activatable probes via spectral characteristics and responsiveness regulation for biological applications, and particularly focus on the molecular design strategy from turn-on mode to ratiometric mode, from aggregation-caused quenching (ACQ) probes to aggregation-induced emission (AIE)-active probes, from near-infrared-I (NIR-I) imaging to NIR-II imaging, and from one-mode to dual-mode of chemo-fluoro-luminescence sensing beta-gal activity.
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