4.7 Article

Synthesis of porphyrin-incorporating covalent organic frameworks for sonodynamic therapy

Journal

CHEMICAL COMMUNICATIONS
Volume 57, Issue 66, Pages 8178-8181

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc02902a

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Funding

  1. National Natural Science Foundation of China [NSFC 21471145]
  2. Science and Technology Development Planning Project of Jilin Province [20170101179JC]
  3. Hundred Talents Program'' of the Chinese Academy of Science

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Porphyrin-incorporating covalent organic frameworks were synthesized with uniform morphology and excellent crystallinity, showing good singlet oxygen generation ability. Both in vitro and in vivo experiments demonstrated significant antitumor efficiency via sonodynamic therapy.
Porphyrin-incorporating covalent organic frameworks were synthesized at room temperature. The resulting products with uniform morphology and excellent crystallinity exhibited good singlet oxygen generation ability. Both in vitro and in vivo experiments demonstrated the significant antitumor efficiency via sonodynamic therapy.

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