Journal
ACS APPLIED BIO MATERIALS
Volume 4, Issue 6, Pages 4907-4916Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.1c00199
Keywords
bone-targeted; osteoporosis; nanoparticles; alendronate; drug carrier
Funding
- basic scientific research operating expenses of provincial universities [SJLY2021002]
- Science and Technology Innovation Commission of Shenzhen [ZDSYS20200811142600003]
- Natural Science Foundation of Guangdong Province [2021A1515010720]
- K. C. Wong Magna Fund in Ningbo University
- Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province
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Alen-decorated nanoparticles were successfully prepared through ionic cross-linking, showing good cytocompatibility and sustained drug release, making them a promising bone-targeted carrier for osteoporosis treatment.
Osteoporosis is a skeletal disorder characterized by a low bone mass and density. Alendronate (Alen), a second-generation bisphosphonate drug, was indicated as the first-line regimen for the treatment of osteoporosis. However, the use of Alen has been limited due to its low bioavailability and gastrointestinal side effects. Herein, Alen-decorated nanoparticles were prepared through ionic cross-linking between poly (lactic-co-glycolic acid), beta-cydodextrin-modified chitosan (PLGA-CS-CD), and Alen-modified alginate (ALG-Alen) for Alen loading and bone-targeted delivery. Alen was selected as a therapeutic drug and a bone-targeting ligand. The nanoparticles have negatively charged surfaces, and sustained release of Alen from the nanoparticles can be observed. Cytotoxicity detected using cell counting kit-8 (CCK-8) assay and lactate dehydrogenase release test on MC3T3 cells showed that the nanoparticles had good cytocompatibility. A hemolysis test showed that the hemolysis ratios of nanoparticles were <5%, indicating that the nanoparticles had no significant hemolysis effect. Moreover, the Alen-decorated nanoparticles exhibited enhanced binding affinity to the hydrox yapatite (HAp) disks compared with that of nanoparticles without Alen modification. Thus, the Alen-decorated nanoparticles might be developed as promising bone-targeted carriers for the treatment of osteoporosis.
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