Journal
AMERICAN JOURNAL OF CANCER RESEARCH
Volume 11, Issue 6, Pages 3320-+Publisher
E-CENTURY PUBLISHING CORP
Keywords
MicroRNA; miR-195; cell proliferation; glycolysis; breast cancer; TCGA; METABRIC; GSEA
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Funding
- NIH [R01CA160688]
- National Cancer Institute (NCI) [P30CA016056]
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MiR-195 is a tumor suppressive microRNA that has been studied in breast cancer using data from two cohorts, showing that low expression of miR-195 is associated with aggressive cancer characteristics and poor prognosis.
MiR-195 is a tumor suppressive microRNA in breast cancer. Its clinical relevance remains debatable as it has only been studied via in vitro experiments or small cohort studies. We analyzed a total of 2,038 patients in the TCGA and METABRIC cohorts to assess whether low miR-195 expressing tumors are associated with aggressive cancer characteristics and poor prognostic outcomes. The median cutoff of miR-195 expression was used to split the groups into miR-195 high and low groups. Low miR-19 expressing tumors demonstrated high cell proliferating features by enriching the gene sets associated with cell proliferation, MKI67 expression and pathological grade. One-third of the top target miR-195 genes were related to cell proliferation. Low miR-195 expressing tumors were associated with both pro-cancerous and anti-cancerous immune cells. Low miR-195 expressing tumors were associated with enhanced glycolysis and poor survival in ER-positive tumors, but not other subtypes of breast cancer. In conclusion, low expression of miR-195 in ER-positive breast cancer was associated with enhanced cancer cell proliferation, glycolysis, and worse overall survival.
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