Journal
JOURNAL OF CANCER
Volume 12, Issue 8, Pages 2456-2464Publisher
IVYSPRING INT PUBL
DOI: 10.7150/jca.48707
Keywords
ERp57/PDIA3; cancer; immune response; immunogenic cell death; unfolded protein response; DNA repair
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Funding
- fundamental research funds for the National Center for Clinical Medicine of Digestive Diseases [2015BAI13B07]
- Natural Science Foundation of China [81430072]
- Scientific Fund for Innovative Research Groups of the National Natural Science Foundation of China [81421003]
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ERp57, a protein belonging to the PDI family, plays important roles in cancer by participating in immune responses, maintaining cell death, regulating unfolded protein response, and influencing cancer growth and progression. Studies suggest that ERp57 could be a potential target for treating cancer and improving chemosensitivity.
Endoplasmic reticulum resident protein 57 (ERp57) has a molecular weight of 57 kDa, belongs to the protein disulfide-isomerase (PDI) family, and is primarily located in the endoplasmic reticulum (ER). ERp57 functions in the quality control of nascent synthesized glycoproteins, participates in major histocompatibility complex (MHC) class I molecule assembly, regulates immune responses, maintains immunogenic cell death (ICD), regulates the unfolded protein response (UPR), functions as a 1,25-dihydroxy vitamin D-3 (1,25(OH)(2)D-3) receptor, regulates the NF-kappa B and STAT3 pathways, and participates in DNA repair processes and cytoskeletal remodeling. Recent studies have reported ERp57 overexpression in various human cancers, and altered expression and aberrant functionality of ERp57 are associated with cancer growth and progression and changes in the chemosensitivity of cancers. ERp57 may become a potential biomarker and therapeutic target to combat cancer development and chemoresistance. Here, we summarize the available knowledge of the role of ERp57 in cancer and the underlying mechanisms.
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