Rh(iii)-Catalyzed one-pot three-component cyclization reaction: rapid selective synthesis of monohydroxy polycyclic BINOL derivatives

A Rh(iii)-catalyzed three-component C-H bond functionalization protocol has been successfully applied to access complex polycyclic BINOL derivatives in which the formation of intermediate amides occurred in situ from aldehydes and amines. The high efficiency strategy allows the rapid selective synthesis of diverse BINOL compounds in a step-economical manner from three readily accessible starting materials in one-pot.

Automated summary

A Rh(iii)-catalyzed three-component C-H bond functionalization protocol has been successfully used to synthesize complex polycyclic BINOL derivatives, with the in situ formation of intermediate amides from aldehydes and amines. This high efficiency strategy allows for rapid and selective synthesis of diverse BINOL compounds in a step-economical manner from three readily accessible starting materials in one-pot.