Journal
EUROPEAN UROLOGY
Volume 71, Issue 2, Pages 168-171Publisher
ELSEVIER
DOI: 10.1016/j.eururo.2016.07.051
Keywords
Prostate cancer; Metastatic castration-resistant prostate cancer; Circulating tumor cells; Docetaxel; Lenalidomide
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Funding
- Celgene Corporation
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Elevated circulating tumor cell (CTC) blood levels (>= 5 cells/7.5 ml) convey a negative prognosis in metastatic castration-resistant prostate cancer but their prognostic significance in patients receiving chemotherapy is uncertain. The association between CTC counts (at baseline or after treatment), overall survival (OS), and response to docetaxelwith lenalidomidewas evaluated in a 208-patient subset fromtheMAINSAIL trial, which compared docetaxel-prednisone-lenalidomide and docetaxel-prednisoneplacebo inmetastatic castration-resistant prostate cancer patients. Baseline CTCswere < 5 cells/7.5 ml blood in 87 (42%) patients and >= 5 cells/7.5 ml in 121 (58%) patients. Neither tumor response nor prostate-specific antigen response correlated with baseline CTCs. However, CTC count >= 5 cells/7.5 ml was significantly associated with lower OS (hazard ratio: 3.23, p = 0.0028). Increases in CTCs from < 5 cells/7.5 ml to >= 5 cells/7.5 ml after three cycleswere associated with significantly shorter OS (hazard ratio: 5.24, p = 0.025), whereas CTC reductions from >= 5 cells/7.5 ml to >= 5 cells/7.5 ml were associated with the best prognosis (p = 0.003). Patient summary: Our study in metastatic castration-resistant prostate cancer patients treated with docetaxel chemotherapy, with or without lenalidomide, showed that patient survival was best predicted by circulating tumor cell count at the start of treatment. A rising circulating tumor cell count after three cycles of therapy predicted poor survival, while a decline predicted good survival. (C) 2016 European Association of Urology. Published by Elsevier B. V. All rights reserved.
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