A critical review of palladium organometallic anticancer agents

With the aim of overcoming the well-known limitations of platinum-based antineoplastic drugs, recent efforts have focused on the development of new anticancer agents containing metals other than platinum. Among these agents, organopalladium compounds have received significant recent attention due to their generally high stability under physiological conditions. A significant number of these compounds have shown promising in vitro and in vivo antiproliferative activity toward several cisplatin-sensitive and cisplatin-resistant tumors and have sometimes exhibited a different mechanism of action compared to platinum- based drugs. In this review, recent advances in the field of organopalladiumcompounds as potential anticancer agents are discussed.

Automated summary

Organopalladium compounds have gained significant attention as potential anticancer agents due to their high stability under physiological conditions, showing promising antiproliferative activity toward cisplatin-sensitive and cisplatin-resistant tumors, and sometimes exhibiting a different mechanism of action compared to platinum-based drugs. Recent advances in this field are discussed in this review.