4.5 Article

Near-infrared emission carbon dots for bio-imaging applications

Journal

NEW CARBON MATERIALS
Volume 36, Issue 3, Pages 632-637

Publisher

ELSEVIER
DOI: 10.1016/S1872-5805(21)60041-0

Keywords

Near-infrared emission; Molecular states; Cellular labelling; Bio-imaging

Funding

  1. National Natural Science Foundation of China [82001962]
  2. China Postdoctoral Science Foundation [2019M661056]
  3. Shanxi Province Science Foundation for Youths [201901D211337]
  4. Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi [2019L0407]

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The near-infrared emitting CDs synthesized in this study exhibit excitation-independent properties and a maximum emission at 692 nm, with good water solubility, exceptional biocompatibility, low toxicity, and superior cellular labelling ability. This work could significantly advance the design and preparation of NIR-CDs and related bio-imaging applications.
It is very difficult to prepare red/near-infrared emission carbon dots (CDs) for bio-imaging applications which are needed because of their deep tissue penetration, minimal auto-fluorescence, and low emission light damage to bio-tissues. Near-infrared emitting CDs (NIR-CDs) were synthesized from sulfonated tetraphenylporphyrin using a solvothermal method. They have excitation-independent properties with a maximum emission at 692 nm. Studies showed that this unique near-infrared emission mainly originated from the aggregated molecular states of the CDs. The NIR-CDs showed good water solubility, exceptional biocompatibility, low toxicity, and superior cellular labelling ability. This work could significantly advance the structural design and preparation of NIR-CDs and corresponding bio-imaging applications.

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