Journal
2021 34TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2021)
Volume -, Issue -, Pages 318-321Publisher
IEEE
DOI: 10.1109/MEMS51782.2021.9375235
Keywords
Breast Cancer; MicroRNA-195; Microfluidics; Biosensor; Field-Effect Transistor; CMOS
Categories
Funding
- Ministry of Science and Technology (MOST) of Taiwan [MOST 107-2221-E-007-013-MY3, MOST 106-2221-E-007-001, MOST 105-2119M007-009]
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Liquid biopsy is a non-invasive method crucial for early diagnosis of breast cancer. The study showed that an integrated microfluidic system using field-effective-transistor biosensors can detect targeted microRNA associated with breast cancer accurately and rapidly.
Breast cancer is one of the leading cancers among women globally with a high mortality rate if not diagnosed in early stages. Liquid biopsy could serve as a non-invasive method for early diagnosis of biomarkers (such as microRNA-195) in blood associated with breast cancer. In this study, we developed an integrated microfluidic system for detecting targeted microRNA-195 by using field-effective-transistor biosensors to quantify an extremely low concentration of microRNA after extraction of extracellular vesicles and microRNAs in plasma. The entire process could be automated with a limit of detection as low as 1 fM. It could be therefore promising for accurate and rapid diagnosis of breast cancer.
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