Journal
CHINESE JOURNAL OF NATURAL MEDICINES
Volume 19, Issue 7, Pages 521-527Publisher
CHINESE JOURNAL NATURAL MEDICINES
DOI: 10.1016/S1875-5364(21)60051-1
Keywords
Hypoxia; Natural product; Human disease; Inhibitor
Funding
- Open Project of State Key Laboratory of Natural Medicines [SKLNMKF 202005]
- Macao Science and Technology Development Fund [071/2017/A2]
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HIF-1, a key transcriptional regulator of metabolic adaptation to oxygen changes, plays important roles in physiological and pathological processes in the body, and is closely linked to the pathogenesis of many diseases.
Hypoxia-inducible factor 1 (HIF-1), as a main transcriptional regulator of metabolic adaptation to changes in the oxygen environment, participates in many physiological and pathological processes in the body, and is closely related to the pathogenesis of many diseases. This review outlines the mechanisms of HIF-1 activation, its signaling pathways, natural inhibitors, and its roles in diseases. This article can provide new insights in the diagnosis and treatment of human diseases, and recent progress on the development of HIF-1 inhibitors.
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