Current Status of Anticoagulant Therapy in Unexplained Recurrent Spontaneous Abortion

Unexplained recurrent spontaneous abortion (URSA) is a difficult problem in obstetrics which often brings serious psychological and economic burden to patients and families, but there is still no effective prevention and treatment method. Some studies suggest that the occurrence of URSA is related to a prethrombotic state and placental vascular thrombosis. The decrease of placental blood perfusion leads to embryonic dysplasia or abortion. Anticoagulant therapy has always been considered by the obstetrics community, but the research opinions are not consistent. With regard to whether anticoagulant drugs such as low-molecular-weight heparin and aspirin can effectively improve pregnancy outcomes of unexplained recurrent spontaneous abortion, this paper collates the relevant data, summarizes the application status of anticoagulant therapy in patients with unexplained recurrent spontaneous abortion, and provides reference for clinical treatment.

Automated summary

Unexplained recurrent spontaneous abortion (URSA) is a challenging issue in obstetrics that may be related to prethrombotic state and placental vascular thrombosis, leading to embryonic dysplasia or abortion. Anticoagulant therapy has been of interest in the obstetrics community, but research findings are inconsistent.