Journal
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
Volume 54, Issue -, Pages -Publisher
SOC BRASILEIRA MEDICINA TROPICAL
DOI: 10.1590/0037-8682-0175-2021
Keywords
Human T-lymphotropic virus 1; Human T-lymphotropic virus 2; Diagnosis; Screening assays; Confirmatory assays; Algorithms
Categories
Funding
- CNPq PQ [312979/20185]
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This study analyzed and reviewed the laboratory diagnosis of human T-lymphotropic virus 1 and 2 (HTLV-1/2) infections in Brazil, including diagnostic serological and molecular assays, causes of false results, and diagnostic flowcharts. The results support the implementation of public policies to reduce HTLV-1/2 transmission.
Introduction: We present a data analysis and review of recent studies regarding the laboratory diagnosis of human T-lymphotropic virus 1 and 2 (HTLV-1/2) infections in Brazil. Methods: Target populations, available diagnostic serological assays (screening and complementary tests), molecular assays (in-house), causes of false-positive and false-negative results, and flowcharts were analyzed. Results: A table presents the target populations, two diagnostic flowcharts (depending on laboratory infrastructure and study population), and recent research that may improve how HTLV-1/2 is diagnosed in Brazil. Conclusions: Our results support the implementation of public policies to reduce HTLV-1/2 transmission and its associated diseases.
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