Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 85, Issue 6, Pages 1526-1529Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bbb/zbab061
Keywords
bitter taste receptor; bitterness masking; dipeptide
Categories
Funding
- Council for Science, Technology and Innovation (CSTI)
- Japan Society for the Promotion of Science (KAKENHI) [JP 18H03195, 18K19753, 19K15792]
- Cross-ministerial Strategic Innovation Promotion Program (SIP) Technologies for creating next-generation agriculture, forestry and fisheries
- Grants-in-Aid for Scientific Research [19K15792, 18K19753] Funding Source: KAKEN
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A novel inhibitor named Trp-Trp was discovered in this study for hTAS2R14, which also showed inhibitory effects on hTAS2R16, hTAS2R43, and hTAS2R46. Its multifunctional characteristic makes it advantageous for being used as bitterness-masking agents in functional foods.
Many functional food ingredients activate human bitter taste receptors (hTAS2Rs). In this study, A novel inhibitor, Trp-Trp, for hTAS2R14 was identified by searching for the agonist peptide's analogs. Trp-Trp also inhibited hTAS2R16, hTAS2R43, and hTAS2R46, which share the same agonists with hTAS2R14. The multifunctional characteristic of Trp-Trp is advantageous for use as bitterness-masking agents in functional foods.
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