Journal
EUROPEAN RADIOLOGY
Volume 27, Issue 12, Pages 5236-5243Publisher
SPRINGER
DOI: 10.1007/s00330-017-4905-x
Keywords
Prostate; MRI; Seminal vesicles; Preparation; Ejaculation
Funding
- Royal College of Radiologists UK
- MRC [MC_UU_00002/6, MC_UP_1302/4] Funding Source: UKRI
- Cancer Research UK [16465] Funding Source: researchfish
- Medical Research Council [MC_UP_1302/4, MC_UU_00002/6] Funding Source: researchfish
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To prospectively investigate the longitudinal effect of ejaculatory abstinence on MRI-measured seminal vesicle (SV) volume and whole-prostate ADC over consecutive days. 15 healthy male volunteers (mean 35.9 years, range 27-53) underwent 3-T MRI at baseline and 1, 2 and 3 days post-ejaculation. Prostate and SV volumes were derived by volume segmentation and whole-gland apparent diffusion coefficient (ADC) values calculated. A mixed-effects linear regression compared ADC values and prostate/seminal vesicle volumes in each volunteer between studies in a pairwise manner. All subjects completed the four MRIs. Mean prostate volume was 22.45 cm(3) (range 13.04-31.21 cm(3)), with no change between the four studies (p = 0.89-0.99). 13/15 subjects showed SV volume reduction from baseline to day 1, with group-mean decreasing from 6.45 to 4.80 cm(3) (-25.6%, p < 0.001), and a significant reduction from baseline to day 2 (-18.1%, p = 0.002). There was a significant volume increase from both day 1 (+21.3%, p = 0.006) and day 2 (+10.2%, p = 0.022) to day 3 post-ejaculation. There was a significant reduction in ADC from 1.105 at baseline to 1.056 x 10(-3) mm(2)/s at day 1 (mean -4.3%, p = 0.009). The longitudinal effect of ejaculation on SV volume was demonstrated. Significant reductions in SV volume and whole-gland ADC were observed post-ejaculation, supporting a 3-day period of abstinence before prostate MRI. aEuro cent Seminal vesicle volume significantly reduced 24 h post-ejaculation remaining reduced at day 2 aEuro cent Seminal vesicle fluid volume significantly increased from day 1 to day 3 post-ejaculation aEuro cent There was a significant reduction in whole-gland prostate ADC values day 1 post-ejaculation aEuro cent 3-day abstinence from ejaculation is required to ensure maximal seminal vesicle distension.
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