Journal
EUROPEAN RADIOLOGY
Volume 27, Issue 11, Pages 4516-4524Publisher
SPRINGER
DOI: 10.1007/s00330-017-4867-z
Keywords
Glioblastoma; Solitary brain metastases; APT imaging; Brain; Magnetic resonance imaging
Funding
- National Natural Science Foundation of China [81171322]
- Natural Science Foundation of Guangdong Province [2014A030313271]
- Guangdong Provincial Science and Technology Project [2014A020212726, S2012010009114]
- Southern Medical University clinical research project [LC2016ZD028]
- National Institutes of Health [R01EB009731, R01CA166171]
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Objectives To determine the utility of amide proton transfer-weighted (APTw) MRimaging in distinguishing solitary brain metastases (SBMs) from glioblastomas (GBMs). Methods Forty-five patients with SBMs and 43 patients with GBMs underwent conventional and APT-weighted sequences before clinical intervention. The APTw parameters and relative APTw (rAPTw) parameters in the tumour core and the peritumoral brain zone (PBZ) were obtained and compared between SBMs and GBMs. The receiver-operating characteristic (ROC) curve was used to assess the best parameter for distinguishing between the two groups. Results The APTw(max), APTw(min), APTw(mean), rAPTw(max), rAPTw(min) or rAPTw(mean) values in the tumour core were not significantly different between the SBM and GBM groups (P = 0.141, 0.361, 0.221, 0.305, 0.578 and 0.448, respectively). However, the APTw(max), APTw(min), APTw(mean), rAPTw(max), rAPTw(min) or rAPTw(mean) values in the PBZ were significantly lower in the SBM group than in the GBM group (P < 0.001). The APTw(min) values had the highest area under the ROC curve 0.905 and accuracy 85.2% in discriminating between the two neoplasms. Conclusion As a noninvasive imaging method, APT-weighted MR imaging can be used to distinguish SBMs from GBMs.
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