Risk stratification of gallbladder polyps larger than 10 mm using high-resolution ultrasonography and texture analysis

To assess important features for risk stratification of gallbladder (GB) polyps > 10 mm using high-resolution ultrasonography (HRUS) and texture analysis. We included 136 patients with GB polyps (> 10 mm) who underwent both HRUS and cholecystectomy (non-neoplastic, n = 58; adenomatous, n = 32; and carcinoma, n = 46). Two radiologists retrospectively assessed HRUS findings and texture analysis. Multivariate analysis was performed to identify significant predictors for neoplastic polyps and carcinomas. Single polyp (OR, 3.680-3.856) and larger size (OR, 1.450-1.477) were independently associated with neoplastic polyps (p < 0.05). In a single or polyp > 14 mm, sensitivity for differentiating neoplastic from non-neoplastic polyps was 92.3%. To differentiate carcinoma from adenoma, sessile shape (OR, 9.485-41.257), larger size (OR, 1.267-1.303), higher skewness (OR, 6.382) and lower grey-level co-occurrence matrices (GLCM) contrast (OR, 0.963) were significant predictors (p < 0.05). In a polyp > 22 mm or sessile, sensitivity for differentiating carcinomas from adenomas was 93.5-95.7%. If a polyp demonstrated at least one HRUS finding and at least one texture feature, the specificity for diagnosing carcinoma was increased to 90.6-93.8%. In a GB polyp > 10 mm, single and diameter > 14 mm were useful for predicting neoplastic polyps. In neoplastic polyps, sessile shape, diameter > 22 mm, higher skewness and lower GLCM contrast were useful for predicting carcinoma. aEuro cent Risk of neoplastic polyp is low in < 14 mm and multiple polyps aEuro cent A sessile polyp or > 22 mm has increased risk for GB carcinomas aEuro cent Higher skewness and lower GLCM contrast are predictors of GB carcinoma aEuro cent HRUS is useful for risk stratification of GB polyps > 1 cm.