Journal
EUROPEAN RADIOLOGY
Volume 28, Issue 5, Pages 2115-2123Publisher
SPRINGER
DOI: 10.1007/s00330-017-5182-4
Keywords
Glioblastoma; O6-methylguanine-DNA methyltransferase; Magnetic resonance imaging; Amide proton transfer-weighted imaging; Methylation
Funding
- National Natural Science Foundation of China [81171322]
- Guangdong Provincial Natural Science Foundation [2014A030313271, S2012010009114]
- Guangdong Provincial Science and Technology Project [2014A020212726]
- Southern Medical University clinical research project [LC2016ZD028]
- National Institutes of Health [R01EB009731, R01CA166171]
- NATIONAL CANCER INSTITUTE [R01CA166171] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB009731] Funding Source: NIH RePORTER
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To explore the feasibility of using amide proton transfer-weighted (APTw) MRI metrics as surrogate biomarkers to identify the O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status in glioblastoma (GBM). Eighteen newly diagnosed GBM patients, who were previously scanned at 3T and had a confirmed MGMT methylation status, were retrospectively analysed. For each case, a histogram analysis in the tumour mass was performed to evaluate several quantitative APTw MRI metrics. The Mann-Whitney test was used to evaluate the difference in APTw parameters between MGMT methylated and unmethylated GBMs, and the receiver-operator-characteristic analysis was further used to assess diagnostic performance. Ten GBMs were found to harbour a methylated MGMT promoter, and eight GBMs were unmethylated. The mean, variance, 50th percentile, 90th percentile and Width(10-90) APTw values were significantly higher in the MGMT unmethylated GBMs than in the MGMT methylated GBMs, with areas under the receiver-operator-characteristic curves of 0.825, 0.837, 0.850, 0856 and 0.763, respectively, for the discrimination of MGMT promoter methylation status. APTw signal metrics have the potential to serve as valuable imaging biomarkers for identifying MGMT methylation status in the GBM population. aEuro cent APTw-MRI is applied to predict MGMT promoter methylation status in GBMs. aEuro cent GBMs with unmethylated MGMT promoter present higher APTw-MRI than methylated GBMs. aEuro cent Multiple APTw histogram metrics can identify MGMT methylation status. aEuro cent Mean APTw values showed the highest diagnostic accuracy (AUC = 0.825).
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