Journal
RESPIRATORY RESEARCH
Volume 22, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12931-021-01792-y
Keywords
Inflammation resolution; Lung diseases; Lung inflammation; Pro-resolving lipid mediators; Mechanism
Categories
Funding
- National Natural Science Foundation of China [81700038, 81870029]
- Beijing Hospitals Authority Youth Programme [QML20180107]
- Capital's Funds for Health Improvement and Research [2018-2-2024]
- Beijing Natural Science Foundation [7204247]
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Inflammation plays a key role in respiratory diseases, and specialized pro-resolving lipid mediators (SPMs) are important in inflammation. A deeper understanding of these inflammation mechanisms and resolution processes is crucial for the development of new treatments and preventive measures.
Inflammation is an essential mechanism of various diseases. The development and resolution of inflammation are complex immune-modulation processes which induce the involvement of various types of immune cells. Specialized pro-resolving lipid mediators (SPMs) have been demonstrated to be signaling molecules in inflammation. SPMs are involved in the pathophysiology of different diseases, especially respiratory diseases, including asthma, pneumonia, and chronic obstructive pulmonary disease. All of these diseases are related to the inflammatory response and its persistence. Therefore, a deeper understanding of the mechanisms and development of inflammation in respiratory disease, and the roles of the SPM family in the resolution process, might be useful in the quest for novel therapies and preventive measures for pulmonary diseases.
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