Related references
Note: Only part of the references are listed.Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Miao-Miao Zhao et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)
A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L
Dibyendu Dana et al.
MOLECULES (2020)
Studies of Thioamide Effects on Serine Protease Activity Enable Two-Site Stabilization of Cancer Imaging Peptides
Taylor M. Barrett et al.
ACS CHEMICAL BIOLOGY (2020)
Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
Xiuyuan Ou et al.
NATURE COMMUNICATIONS (2020)
Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients
Tianxiao Liu et al.
PHARMACOLOGY & THERAPEUTICS (2020)
COVID-19: Drug Targets and Potential Treatments
Carmen Gil et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Rosetta Machine Learning Models Accurately Classify Positional Effects of Thioamides on Proteolysis
Sam Giannakoulias et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2020)
Improved Modeling of Thioamide FRET Quenching by Including Conformational Restriction and Coulomb Coupling
Jimin Yoon et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2020)
Cell penetrable, clickable and tagless activity-based probe of human cathepsin L
Dibyendu Dana et al.
BIOORGANIC CHEMISTRY (2019)
Fluorescent Probes for Studying Thioamide Positional Effects on Proteolysis Reveal Insight into Resistance to Cysteine Proteases
Chunxiao Liu et al.
CHEMBIOCHEM (2019)
A Comprehensive Review on Current Advances in Peptide Drug Development and Design
Andy Chi-Lung Lee et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Biosynthesis and Chemical Applications of Thioamides
Nilkamal Mahanta et al.
ACS CHEMICAL BIOLOGY (2019)
The Current State of Peptide Drug Discovery: Back to the Future?
Antoine Henninot et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Increasing the bioactive space of peptide macrocycles by thioamide substitution
Hitesh Verma et al.
CHEMICAL SCIENCE (2018)
Thioamide Substitution Selectively Modulates Proteolysis and Receptor Activity of Therapeutic Peptide Hormones
Xing Chen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Peptide therapeutics: current status and future directions
Keld Fosgerau et al.
DRUG DISCOVERY TODAY (2015)
Proteomic Identification of Cysteine Cathepsin Substrates Shed from the Surface of Cancer Cells
Barbara Sobotic et al.
MOLECULAR & CELLULAR PROTEOMICS (2015)
Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response
Oakley C. Olson et al.
NATURE REVIEWS CANCER (2015)
Thioamide-Based Fluorescent Protease Sensors
Jacob M. Goldberg et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Identification of a Broad-Spectrum Antiviral Small Molecule against Severe Acute Respiratory Syndrome Coronavirus and Ebola, Hendra, and Nipah Viruses by Using a Novel High-Throughput Screening Assay
Hatem A. Elshabrawy et al.
JOURNAL OF VIROLOGY (2014)
Increased Expression of Cathepsin L: A Novel Independent Prognostic Marker of Worse Outcome in Hepatocellular Carcinoma Patients
Jian Ruan et al.
PLOS ONE (2014)
The Future of Peptide-based Drugs
David J. Craik et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2013)
Thioamide Quenching of Fluorescent Probes through Photoinduced Electron Transfer: Mechanistic Studies and Applications
Jacob M. Goldberg et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Selective cancer targeting with prodrugs activated by histone deacetylases and a tumour-associated protease
Nobuhide Ueki et al.
NATURE COMMUNICATIONS (2013)
Cysteine cathepsins: From structure, function and regulation to new frontiers
Vito Turk et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2012)
Protease-resistant peptide designuempowering nature's fragile warriors against HIV
Matthew T. Weinstock et al.
BIOPOLYMERS (2012)
New, Potent, Selective, and Short-Acting Peptidic V1a Receptor Agonists
Kazimierz Wisniewski et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Proteomic Identification of Protease Cleavage Sites Characterizes Prime and Non-prime Specificity of Cysteine Cathepsins B, L, and S
Martin L. Biniossek et al.
JOURNAL OF PROTEOME RESEARCH (2011)
The resurgence of covalent drugs
Juswinder Singh et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
PyRosetta: a script-based interface for implementing molecular modeling algorithms using Rosetta
Sidhartha Chaudhury et al.
BIOINFORMATICS (2010)
Impaired turnover of autophagolysosomes in cathepsin L deficiency
Julia Dennemaerker et al.
BIOLOGICAL CHEMISTRY (2010)
Strategies for discovering and derisking covalent, irreversible enzyme inhibitors
Douglas S. Johnson et al.
FUTURE MEDICINAL CHEMISTRY (2010)
Specialized roles for cysteine cathepsins in health and disease
Jochen Reiser et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Emerging principles in protease-based drug discovery
Marcin Drag et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Unique biological function of cathepsin L in secretory vesicles for biosynthesis of neuropeptides
Lydiane Funkelstein et al.
NEUROPEPTIDES (2010)
Sub-angstrom modeling of complexes between flexible peptides and globular proteins
Barak Raveh et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2010)
Cathepsin L inhibition suppresses drug resistance in vitro and in vivo: a putative mechanism
Xin Zheng et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)
Dipeptidyl nitrile inhibitors of Cathepsin L
Nabil Asaad et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3β signaling
Qizhu Tang et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2009)
Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor
Michael C. Myers et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Structure-activity relationships of Bak derived peptides: Affinity and specificity modulations by amino acid replacement
Virginie Frey et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2008)
Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L
Parag P. Shah et al.
MOLECULAR PHARMACOLOGY (2008)
Cell type-specific functions of the lysosomal protease cathepsin L in the heart
Daniel Spira et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Targeting proteases: successes, failures and future prospects
Boris Turk
NATURE REVIEWS DRUG DISCOVERY (2006)
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis
JA Joyce et al.
CANCER CELL (2004)
Cysteine cathepsins in human cancer
C Jedeszko et al.
BIOLOGICAL CHEMISTRY (2004)
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter
S Yasothornsrikul et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Human and mouse proteases:: A comparative genomic approach
XS Puente et al.
NATURE REVIEWS GENETICS (2003)
Design and synthesis of dipeptide nitriles as reversible and potent cathepsin S inhibitors
YD Ward et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L
J Stypmann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design
PD Greenspan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
Strategies for the inhibition of serine proteases
B Walker et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2001)
Crystal structure of human cathepsin V
JR Somoza et al.
BIOCHEMISTRY (2000)