Silicon compounds as stoichiometric coupling reagents for direct amidation

Despite being one of the most frequently carried out chemical reactions in industry, there is currently no amidation protocol that is regarded as safe, high yielding, environmentally friendly and inexpensive. The direct amidation of a carboxylic acid with an amine is viewed as an inherently good solution for developing such a protocol. Since the 1960s, there has been a gradual development in the use of silicon reagents for direct amidation. This review covers the methods published to April 2021 for silicon reagent mediated direct amidation of a carboxylic acid with an amine. This review also covers the use of polymeric SiO2 to promote direct amidation.

Automated summary

Amidation is a common chemical reaction in industry, but there is currently no widely recognized safe, high-yielding, environmentally friendly, and inexpensive amidation protocol. Direct amidation of a carboxylic acid with an amine is seen as a potential solution to this problem. The gradual development and use of silicon reagents for direct amidation since the 1960s is covered in this review, along with the methods published up to April 2021 related to silicon reagent-mediated direct amidation of a carboxylic acid with an amine.