Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 65, Pages 8035-8038Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc03079e
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Funding
- CNRS-Israel Ministry of Science joint program [223851/U2NMR, 3-14888]
- European Research Council (ERC) under the European Union [801774/DINAMIX, 814747/SUMMIT]
- Region Pays de la Loire (Connect Talent)
- Israel Science Foundation [965/18]
- Perlman Family Foundation
- French National Infrastructure for Metabolomics and Fluxomics Metabo [HUB-ANR-11-INBS-0010]
- Corsaire metabolomics core facility (Biogenouest)
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By utilizing dissolution dynamic nuclear polarisation (D-DNP) hyperpolarisation, optimized transfer settings, and ultrafast 2D NMR experiments, TOCSY and MQ spectra can be obtained for mixture analysis, leading to significant sensitivity gains for analytical applications of NMR such as authentication and metabolomics.
We show that TOCSY and multiple-quantum (MQ) 2D NMR spectra can be obtained for mixtures of substrates hyperpolarised by dissolution dynamic nuclear polarisation (D-DNP). This is achieved by combining optimised transfer settings for D-DNP, with ultrafast 2D NMR experiments based on spatiotemporal encoding. TOCSY and MQ experiments are particularly well suited for mixture analysis, and this approach opens the way to significant sensitivity gains for analytical applications of NMR, such as authentication and metabolomics.
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