Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 9, Issue 30, Pages 6076-6083Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1tb00582k
Keywords
-
Categories
Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2020R1A4A407983711]
Ask authors/readers for more resources
A novel biosensor was developed to detect NES1 with high sensitivity, capable of detecting low levels of NES1 even in the presence of other interfering biomolecules. The a-MPCNF-based FET sensor showed promising potential for practical applications in non-invasive real-time diagnosis, as demonstrated by its sensing performance in artificial saliva.
Nesfatin-1 (NES1) is a potential biomarker found in serum and saliva that indicates hyperpolarization and depolarization in the hypothalamic ventricle nucleus as well as an increase in epileptic conditions. However, real-time investigations have not been carried out to detect changes in the concentration of NES1. In this study, we develop a multiscale pore contained carbon nanofiber-based field-effect transistor (FET) biosensor to detect NES1. The activated multiscale pore contained carbon nanofiber (a-MPCNF) is generated using a single-nozzle co-electrospinning method and a subsequent steam-activation process to obtain a signal transducer and template for immobilization of bioreceptors. The prepared biosensor exhibits a high sensitivity to NES1. It can detect levels as low as 0.1 fM of NES1, even in the presence of other interfering biomolecules. Furthermore, the a-MPCNF-based FET sensor has significant potential for practical applications in non-invasive real-time diagnosis, as indicated by its sensing performance in artificial saliva.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available