Journal
CHINESE JOURNAL OF ORGANIC CHEMISTRY
Volume 41, Issue 5, Pages 1878-1887Publisher
SCIENCE PRESS
DOI: 10.6023/cjoc202010026
Keywords
medium-sized ring; macrocycle; ring expansion reaction; cyclization
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Funding
- Student's Platform for Innovation and Entrepreneurship Training Program [201910613081]
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Medium-sized rings and macrocycles, which are crucial components in drugs and natural products, have attracted significant attention from chemists in developing simple, green, and efficient synthesis methods. Recent advancements in ring expansion/cyclization reactions for these compounds have been reviewed to outline the future prospects and development in this field.
Medium-sized rings (8 similar to 11 membered ring) and macrocycles (12-membered rings and above) are extremely important parts of drug and natural products. Meanwhile, they are widely used in the field of medicinal chemistry, organic chemistry and other fields. Developing simple, green and efficient protocol to synthesize medium-sized rings and macrocycles has attracted great interests from chemists in the recent years. The latest ring expansion/cyclization reaction in the synthesis of medium-sized ring and macrocyclic compounds in the past five years is reviewed, and the prospect of their future and development is also outlined.
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