Journal
CHEMICAL SOCIETY REVIEWS
Volume 50, Issue 17, Pages 9766-9793Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cs01124j
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Funding
- Singapore National Research Foundation, Prime Minister's Office [R-143-000-A15-281]
- National University of Singapore [C-141-000-092-001]
- Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia [DRI 74]
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The past two decades have seen remarkable growth of asymmetric organocatalysis, serving as a powerful platform for producing chiral molecules. Ring structures are widely present in organic compounds, and strategic construction of ring motifs is crucial in natural product synthesis.
The past two decades have witnessed remarkable growth of asymmetric organocatalysis, which is now a firmly established synthetic tool, serving as a powerful platform for the production of chiral molecules. Ring structures are ubiquitous in organic compounds, and, in the context of natural product synthesis, strategic construction of ring motifs is often crucial, fundamentally impacting the eventual fate of the whole synthetic plan. In this review, we provide a comprehensive and updated summary of asymmetric organocatalytic annulation reactions; in particular, the application of these annulation strategies in natural product synthesis will be highlighted.
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