Related references
Note: Only part of the references are listed.PROTAC-DB: an online database of PROTACs
Gaoqi Weng et al.
NUCLEIC ACIDS RESEARCH (2021)
The Rise of Molecular Glues
Stuart L. Schreiber
CELL (2021)
Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1
Adam D. Cotton et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)
Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase
Yun Ge et al.
NATURE CHEMICAL BIOLOGY (2021)
LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation
Green Ahn et al.
NATURE CHEMICAL BIOLOGY (2021)
ATTEC: a potential new approach to target proteinopathies
Zhaoyang Li et al.
AUTOPHAGY (2020)
Engineering a Proximity-Directed O-GlcNAc Transferase for Selective Protein O-GlcNAcylation in Cells
Daniel H. Ramirez et al.
ACS CHEMICAL BIOLOGY (2020)
Heterobifunctional Molecules Induce Dephosphorylation of Kinases-A Proof of Concept Study
Sayumi Yamazoe et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Pan-cancer analysis of whole genomes
Peter J. Campbell et al.
NATURE (2020)
Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer
Matthew G. Costales et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Prey for the Proteasome: Targeted Protein Degradation-A Medicinal Chemist's Perspective
Laura M. Luh et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)
Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol
Lu Zhang et al.
SCIENCE (2020)
Emerging New Concepts of Degrader Technologies
Yu Ding et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2020)
Multispecific drugs herald a new era of biopharmaceutical innovation
Raymond J. Deshaies
NATURE (2020)
Unifying principles of bifunctional, proximity-inducing small molecules
Christopher J. Gerry et al.
NATURE CHEMICAL BIOLOGY (2020)
Protein transmission in neurodegenerative disease
Chao Peng et al.
NATURE REVIEWS NEUROLOGY (2020)
Phosphorylation-Inducing Chimeric Small Molecules
Sachini U. Siriwardena et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation
Zilei Liu et al.
CELL (2020)
Lysosome-targeting chimaeras for degradation of extracellular proteins
Steven M. Banik et al.
NATURE (2020)
PRosettaC: Rosetta Based Modeling of PROTAC Mediated Ternary Complexes
Daniel Zaidman et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)
Targeted glycan degradation potentiates the anticancer immune response in vivo
Melissa A. Gray et al.
NATURE CHEMICAL BIOLOGY (2020)
Global view of human protein glycosylation pathways and functions
Katrine T. Schjoldager et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
Targeting the SARS-CoV-2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders
Hafeez S. Haniff et al.
ACS CENTRAL SCIENCE (2020)
Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants
Sumaiya Iqbal et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Small molecule recognition of disease-relevant RNA structures
Samantha M. Meyer et al.
CHEMICAL SOCIETY REVIEWS (2020)
In Situ Fucosylation of the Wnt Co-receptor LRP6 Increases Its Endocytosis and Reduces Wnt/β-Catenin Signaling
Senlian Hong et al.
CELL CHEMICAL BIOLOGY (2020)
Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications
Carl C. Ward et al.
ACS CHEMICAL BIOLOGY (2019)
Targeted protein degradation: elements of PROTAC design
Stacey-Lynn Paiva et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2019)
Harnessing the anti-cancer natural product nimbolide for targeted protein degradation
Jessica N. Spradlin et al.
NATURE CHEMICAL BIOLOGY (2019)
Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16
Xiaoyu Zhang et al.
NATURE CHEMICAL BIOLOGY (2019)
Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations
Melissanne de Wispelaere et al.
NATURE COMMUNICATIONS (2019)
Bifunctional Small-Molecule Ligands of K-Ras Induce Its Association with Immunophilin Proteins
Ziyang Zhang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)
Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds
Zhaoyang Li et al.
NATURE (2019)
AUTACs: Cargo-Specific Degraders Using Selective Autophagy
Daiki Takahashi et al.
MOLECULAR CELL (2019)
Emerging modes-of-action in drug discovery
Eric Valeur et al.
MEDCHEMCOMM (2019)
Targeted Degradation of a Hypoxia-Associated Non-coding RNA Enhances the Selectivity of a Small Molecule Interacting with RNA
Matthew G. Costales et al.
CELL CHEMICAL BIOLOGY (2019)
PROTACs: great opportunities for academia and industry
Xiuyun Sun et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)
FGFR1-Activated Translation of WNT Pathway Components with Structured 5′ UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation
Tuan M. Nguyen et al.
CANCER RESEARCH (2018)
Small Molecule Targeted Recruitment of a Nuclease to RNA
Matthew G. Costales et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Chemically induced proximity in biology and medicine
Benjamin Z. Stanton et al.
SCIENCE (2018)
Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action
Kristin M. Riching et al.
ACS CHEMICAL BIOLOGY (2018)
Induced protein degradation: an emerging drug discovery paradigm
Ashton C. Lai et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders
Scott J. Hughes et al.
STRUCTURE-BASED DRUG DESIGN: INSIGHTS FROM ACADEMIA AND INDUSTRY (2017)
The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy
Fatima Ardito et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)
Genomics and evolution of protein phosphatases
Mark J. Chen et al.
SCIENCE SIGNALING (2017)
Genomics and evolution of protein phosphatases
Mark J. Chen et al.
SCIENCE SIGNALING (2017)
E3 ubiquitin ligases in cancer and implications for therapies
Dong Wang et al.
CANCER AND METASTASIS REVIEWS (2017)
Defining a Cancer Dependency Map
Aviad Tsherniak et al.
CELL (2017)
A Systems Biology Approach Identifies FUT8 as a Driver of Melanoma Metastasis
Praveen Agrawal et al.
CANCER CELL (2017)
Precision glycocalyx editing as a strategy for cancer immunotherapy
Han Xiao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
Chia-Wei Li et al.
NATURE COMMUNICATIONS (2016)
A Small Molecule That Inhibits OGT Activity in Cells
Rodrigo F. Ortiz-Meoz et al.
ACS CHEMICAL BIOLOGY (2015)
The demographics of the ubiquitin system
Michael J. Clague et al.
TRENDS IN CELL BIOLOGY (2015)
RSK2 regulates endocytosis of FGF receptor 1 by phosphorylation on serine 789
B. Nadratowska-Wesolowska et al.
ONCOGENE (2014)
Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology
Catharina Steentoft et al.
EMBO JOURNAL (2013)
A Comprehensive Mathematical Model for Three-Body Binding Equilibria
Eugene F. Douglass et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains
Shan Li et al.
NATURE (2013)
Large-scale identification of ubiquitination sites by mass spectrometry
Namrata D. Udeshi et al.
NATURE PROTOCOLS (2013)
MHC Class I-Associated Phosphopeptides Are the Targets of Memory-like Immunity in Leukemia
Mark Cobbold et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Rewiring Kinase Specificity with a Synthetic Adaptor Protein
Elissa M. Hobert et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling
Guoqiang Xu et al.
NATURE BIOTECHNOLOGY (2010)
Cracking the Phosphatase Code: Docking Interactions Determine Substrate Specificity
Jagoree Roy et al.
SCIENCE SIGNALING (2009)
A glycopeptide in complex with MHC class I uses the GaINAc residue as an anchor
V Apostolopoulos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Dimerizer-induced proliferation of genetically modified hepatocytes
ZY Li et al.
MOLECULAR THERAPY (2002)
Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation
KM Sakamoto et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Share Paper
