Journal
RSC ADVANCES
Volume 11, Issue 37, Pages 22556-22564Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ra02841c
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Funding
- National Key Research and Development Program of China [2016YFA0201600]
- National Natural Science Foundation of China [U2032206]
- Science and Technology Service Network Project (STS Program) of the Chinese Academy of Sciences [KFJ-STS-ZDTP-063]
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A new anti-fouling CNT-PEG-hydrogel film-coated QCM sensor was developed for highly sensitive detection of saliva glucose. This tool offers high stability, specificity, and selectivity, making it a promising tool for non-invasive monitoring of saliva glucose at human physiological levels.
Saliva glucose detection based on a quartz crystal microbalance (QCM) sensor has emerged as a promising tool and a non-invasive diagnostic technique for diabetes. However, the low glucose concentration and strong protein interference in the saliva hinder the QCM sensors from practical applications. In this study, we present a robust and simple anti-fouling CNT-PEG-hydrogel film-coated QCM sensor for the detection of saliva glucose with high sensitivity. The CNT-PEG-hydrogel film consists of two layers; the bottom base PBA-hydrogel film is designed to recognize the glucose while the top CNT-PEG layer is used to restrict protein adsorption and improve the biocompatibility. Our results show that this CNT-PEG-hydrogel film exhibited a 10-fold enhancement on the detection limit compared to the PBA-hydrogel. Meanwhile, the adsorption of proteins on the surface of the CNT-PEG-hydrogel film, including bovine serum albumin (BSA), mucin (MUC), and fibrinogen (FIB), were reduced by 99.1%, 77.8%, and 83.7%, respectively. The CNT-PEG-hydrogel film could detect the typical saliva glucose level (0-50 mg L-1) in 10% saliva with a good responsivity. To sum up, this new tool with low-fouling film featuring high stability, specificity, and selectivity holds great potential for non-invasive monitoring of saliva glucose in human physiological levels.
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