Journal
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
Volume 8, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/jcdd8070080
Keywords
statins; renin-angiotensin system (RAS); hypertension
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Statins not only lower serum LDL-cholesterol, but also have important effects on the renin-angiotensin system pathway, offering new therapeutic possibilities beyond cholesterol lowering.
Statins, a class of drugs for lowering serum LDL-cholesterol, have attracted attention because of their wide range of pleiotropic effects. An important but often neglected effect of statins is their role in the renin-angiotensin system (RAS) pathway. This pathway plays an integral role in the progression of several diseases including hypertension, heart failure, and renal disease. In this paper, the role of statins in the blockade of different components of this pathway and the underlying mechanisms are reviewed and new therapeutic possibilities of statins are suggested.
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