Journal
BIOMATERIALS SCIENCE
Volume 9, Issue 17, Pages 5951-5964Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1bm00622c
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Funding
- National Natural Science Foundation of China [31870986, 81271689, 31271009]
- Natural Science Foundation of Fujian Province of China [2020J01036]
- Program for New Century Excellent Talents in University
- Fundamental Research Funds for the Central Universities [20720150087]
- Foundation of Xiamen Science and Technology Bureau [3502Z20209208]
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The study found that Cu(ii) loaded PDA nanoparticles showed the best antibacterial and wound healing capabilities, with good blood compatibility and low cytotoxicity. The slow release of copper ions from the nanoparticles and the synergistic antibacterial effect of phenolic hydroxyl and amine groups in PDA NPs contributed to their excellent performance in preventing wound infection and promoting healing.
Melanin and its analogue polydopamine (PDA) have attracted considerable attention in biomedical science due to their surface-rich metal binding sites, excellent adhesion and good biocompatibility. Bacterial infections at the wound site and uncontrolled bleeding are associated with a high risk of death, and the prevention of wound infections remains a major challenge. On this basis, the four nanoparticles (NPs) of melanin, PDA, copper ion-loaded melanin (Cu(ii) loaded melanin) and copper ion-loaded PDA (Cu(ii) loaded PDA) were studied in terms of antibacterial and wound healing capabilities. The in vitro experiments showed that Cu(ii) loaded PDA NPs had good blood compatibility and low cytotoxicity, showing the best antibacterial effect in comparison with other samples. Not only could the slow release of copper ions from the nanoparticles kill bacteria, but also the phenolic hydroxyl group and amine groups of PDA NPs played a synergistic role in bacterial death. In wound healing experiments, the Cu(ii) loaded PDA NPs could easily and tightly bind with biological tissue, demonstrating excellent hemostasis, antibacterial and wound healing capabilities. In summary, the excellent properties of Cu(ii) loaded PDA NPs made them a safe and effective drug for preventing wound infection and promoting healing.
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