Journal
EUROPEAN PSYCHIATRY
Volume 45, Issue -, Pages 81-89Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.eurpsy.2017.05.001
Keywords
Familial liability; Multimorbidity; Physical health; Psychosis; Schizophrenia
Categories
Funding
- Geestkracht programme of the Dutch Health Research Council (Zon-Mw) [10-000-1001]
- Lundbeck
- AstraZeneca
- Eli Lilly
- Janssen Cilag
- Amsterdam: Academic Psychiatric Centre of the Academic Medical Center
- mental health institution: GGZ Ingeest
- mental health institution: Arkin
- mental health institution: Dijk en Duin
- mental health institution: GGZ Rivierduinen
- mental health institution: Erasmus Medical Centre
- mental health institution: GGZ Noord Holland Noord
- University Medical Center Groningen
- mental health institution: Lentis
- mental health institution: GGZ Friesland
- mental health institution: GGZ Drenthe
- mental health institution: Dimence
- mental health institution: Mediant
- mental health institution: GGNet Warnsveld
- mental health institution: Yulius Dordrecht
- mental health institution: Parnassia psycho-medical center The Hague
- Maastricht University Medical Centre
- mental health institution: GGZ Eindhoven en De Kempen
- mental health institution: GGZ Breburg
- mental health institution: GGZ Oost-Brabant
- mental health institution: Vincent van Gogh voor Geestelijke Gezondheid
- mental health institution: Mondriaan
- mental health institution: Virenze riagg
- mental health institution: Zuyderland GGZ
- mental health institution: MET ggz
- mental health institution: Universitair Centrum Sint-Jozef Kortenberg
- mental health institution: CAPRI University of Antwerp
- mental health institution: PC Ziekeren Sint-Truiden
- mental health institution: PZ Sancta Maria Sint-Truiden
- mental health institution: GGZ Overpelt
- mental health institution: OPZ Rekem
- University Medical Center Utrecht
- mental health institution Altrecht
- mental health institution GGZ Centraal
- mental health institution Delta
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Background: Multimorbidity may impose an overwhelming burden on patients with psychosis and is affected by gender and age. Our aim is to study the independent role of familial liability to psychosis as a risk factor for multimorbidity. Methods: We performed the study within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) project. Overall, we compared 1024 psychotic patients, 994 unaffected siblings and 566 controls on the prevalence of 125 lifetime diseases, and 19 self-reported somatic complaints. Multimorbidity was defined as the presence of two or more complaints/diseases in the same individual. Generalized linear mixed model (GLMM) were used to investigate the effects of gender, age (adolescent, young, older) and familial liability (patients, siblings, controls) and their interactions on multimorbidity. Results: Familial liability had a significant effect on multimorbidity of either complaints or diseases. Patients had a higher prevalence of multimorbidity of complaints compared to siblings (OR 2.20, 95% CI 1.79-2.69, P < 0.001) and to controls (3.05, 2.35-3.96, P < 0.001). In physical health multimorbidity, patients (OR 1.36, 95% CI 1.05-1.75, P = 0.018), but not siblings, had significantly higher prevalence than controls. Similar finding were observed for multimorbidity of lifetime diseases, including psychiatric diseases. Significant results were observed for complaints and disease multimorbidity across gender and age groups. Conclusion: Multimorbidity is a common burden, significantly more prevalent in patients and their unaffected siblings. Familial liability to psychosis showed an independent effect on multimorbidity; gender and age are also important factors determining multimorbidity. (C) 2017 Elsevier Masson SAS. All rights reserved.
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