Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 67, Pages 8320-8323Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc02102h
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Funding
- National Natural Science Foundation of China [21907060, 91753111, 21775093, 21927811, 21877076]
- Key Research and Development Program of Shandong Province [2018YFJH0502]
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A light-activatable photosensitizer based on a diarylethene derivative was developed for photodynamic therapy, showing sufficient therapeutic effects on HeLa cells. The opened form of DAE-TPE NPs was converted to the closed form upon UV exposure, activating photosensitization.
Herein, a light-activatable photosensitizer based on a diarylethene derivative, DAE-TPE, was developed for photodynamic therapy. Upon UV exposure, the opened form (OF) of DAE-TPE NPs was converted to the closed form (CF), and photosensitization was activated. The CF of DAE-TPE NPs exhibited sufficient photodynamic therapy effects upon HeLa cells.
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