Journal
MOLECULES
Volume 26, Issue 14, Pages -Publisher
MDPI
DOI: 10.3390/molecules26144354
Keywords
droplet microfluidics; assisted reproductive technology; fertilization in vitro; sperm and oocyte; embryo culture
Funding
- Taiwan Ministry of Science and Technology [MOST 109-2622-E-007-008, 1092321-B-182A-006]
- Chang Gung Memorial Hospital Research Grants [CMRPG3H1661, CMRPG3K0781]
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Infertility refers to the inability to achieve pregnancy after 12 or more months of regular unprotected sexual intercourse. Assisted reproductive technology (ART) plays a crucial role in addressing infertility, with techniques like IVF, ICSI, and IUI being commonly used. Microfluidic technologies can enhance ART procedures by incorporating various techniques for analysis, manipulation, and monitoring of embryos and gametes.
Infertility is a state of the male or female reproductive system that is defined as the failure to achieve pregnancy even after 12 or more months of regular unprotected sexual intercourse. Assisted reproductive technology (ART) plays a crucial role in addressing infertility. Various ART are now available for infertile couples. Fertilization in vitro (IVF), intracytoplasmic sperm injection (ICSI) and intrauterine insemination (IUI) are the most common techniques in this regard. Various microfluidic technologies can incorporate various ART procedures such as embryo and gamete (sperm and oocyte) analysis, sorting, manipulation, culture and monitoring. Hence, this review intends to summarize the current knowledge about the application of this approach towards cell biology to enhance ART.
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