Journal
RSC ADVANCES
Volume 11, Issue 40, Pages 24570-24574Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ra05032j
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Funding
- Department of Science and Technology (DST), Government of India [IFA-13 CH-98]
- NITK, Surathkal
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Direct synthesis of 4H-benzo[d][1,3]dioxin-4-one derivatives from salicylic acids and acetylenic esters (both mono- and disubstituted) has been achieved using CuI and NaHCO3 in acetonitrile. The subsequent amidation of the synthesized 1,3-benzodioxinones with primary amines readily produced salicylamides in moderate to good yields at room temperature.
Direct synthesis of 4H-benzo[d][1,3]dioxin-4-one derivatives from salicylic acids and acetylenic esters (both mono- and disubstituted) has been described. The reaction is mediated by CuI and NaHCO3 in acetonitrile. Room temperature amidation of the synthesized 1,3-benzodioxinones with primary amines readily afforded the corresponding salicylamides in moderate to good yields.
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