4.6 Article

Prognostic value of fatty acid metabolism-related genes in patients with hepatocellular carcinoma

Journal

AGING-US
Volume 13, Issue 13, Pages 17847-17863

Publisher

IMPACT JOURNALS LLC

Keywords

hepatocellular carcinoma; TCGA; ICGC; fatty acid metabolism; prognosis

Funding

  1. youth scientific research project of Fujian provincial health and family planning commission [2017-2-80]
  2. project of Putian science and technology department [2020SY006]
  3. Key Clinical Specialty Construction Project of Putian city [2021-2023]

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A prognostic model based on fatty acid metabolism-related genes was constructed for HCC patients, showing superior predictive capacities. The study also investigated immune cell infiltration in the tumor microenvironment, revealing correlations with different risk levels.
The deregulation of fatty acid metabolism plays a crucial role in cancer. However, the prognostic value of genes involved in the metabolism in hepatocellular carcinoma (HCC) remains largely unknown. We first constructed a multi-fatty acid metabolic gene prognostic model of HCC based on The Cancer Genome Atlas (TCGA) and further validated it using the International Cancer Genome Consortium (ICGC) database. The model was integrated with the clinical parameters, and a nomogram was built and weighted. Moreover, immune cell infiltration of the tumor microenvironment was investigated. A prognostic model was constructed using 6 selected fatty acid metabolism-related genes, and HCC patients were divided into high- and low-risk groups. Receiver operating characteristic curve (ROC) analysis, principal component analysis (PCA), and t-distributed stochastic neighbor embedding (t-SNE) analysis showed the optimal performance of the model. The concordance index (C-index), ROC curve, calibration plot and decision curve analysis (DCA) all confirmed the satisfactory predictive capacity of the nomogram. The analysis of immune cell infiltration in HCC patients revealed a correlation with different risk levels. Our findings indicate that a prognostic model based on fatty acid metabolism-related genes has superior predictive capacities, which provides the possibility for further improving the individualized treatment of patients with HCC.

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