Journal
THERANOSTICS
Volume 11, Issue 17, Pages 8412-8429Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.59092
Keywords
Iron metabolism; Cancer; Therapy; Chelation; Ferroptosis
Categories
Funding
- National Institutes of Health [P20 GM130422]
- American Cancer Society [RSG-18-050-01-NEC]
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Iron is crucial for cellular functions and human health, but excess iron can lead to oxidative DNA damage and cancer. Cancer cells are more dependent on iron than normal cells, making targeting iron metabolism in cancer cells an emerging and powerful therapeutic strategy.
Iron is a critical component of many cellular functions including DNA replication and repair, and it is essential for cell vitality. As an essential element, iron is critical for maintaining human health. However, excess iron can be highly toxic, resulting in oxidative DNA damage. Many studies have observed significant associations between iron and cancer, and the association appears to be more than just coincidental. The chief characteristic of cancers, hyper-proliferation, makes them even more dependent on iron than normal cells. Cancer therapeutics are becoming as diverse as the disease itself. Targeting iron metabolism in cancer cells is an emerging, formidable field of therapeutics. It is a strategy that is highly diverse with regard to specific targets and the various ways to reach them. This review will discuss the importance of iron metabolism in cancer and highlight the ways in which it is being explored as the medicine of tomorrow.
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