Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 9, Issue 34, Pages 6802-6810Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1tb00867f
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Funding
- National Natural Science Foundation of China [81925027, 31530024, 82002275, 31872748]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX20_2690]
- Jiangsu Provincial Special Program of Medical Science [BL2012004]
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [20KJB430041]
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Calcium phosphate cement with enhanced washout resistance and mechanical properties has potential for future clinical applications as bone filling materials.
Calcium phosphate cement (CPC), which exhibits excellent biocompatibility and bioactivity, is a well-established material for the repair of bone defects. However, its disadvantages such as poor washout resistance and low mechanical strength limit its clinical applications. In this study, CPC with enhanced washout resistance and mechanical properties has been developed by the in situ crosslinking of glycidyl methacrylate modified gamma-polyglutamic acid (m-PGA) within the cement matrix, forming an interpenetrating network. Compared with unmodified CPC, the final setting time of the composite cements was shortened and its washout resistance was significantly improved. In addition, the composite cements showed enhanced mechanical strength and degradation properties. An in vitro study demonstrated that the composite cements exhibited good biocompatibility. The in vivo results showed that the composite cements promoted bone formation. These results suggest that the biocompatible, injectable alpha-tricalcium phosphate (alpha-TCP)/m-PGA cements may have the potential to be used as bone filling materials for future clinical applications.
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