Journal
GREEN CHEMISTRY
Volume 23, Issue 16, Pages 5753-5758Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1gc02107a
Keywords
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Funding
- Natural Science Foundation of China [21776254]
- Zhejiang Provincial Natural Science Foundation of China [LQ20B060006]
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A versatile C(sp(2))-C(sp(3)) bond formation catalyzed by K2S2O8 with N-heteroaromatics and gamma-lactams/amides has been developed. The reaction proceeds in moderate to good yields with high regioselectivity under visible-light-induced photocatalyst-free conditions in H2O at ambient temperature. The new K2S2O8 catalytic mechanism was investigated through control experiments.
A K2S2O8-catalyzed versatile C(sp(2))-C(sp(3)) bond formation with N-heteroaromatics and gamma-lactams/amides was developed. Quinoxalin-2(1H)-one, quinoline, isoquinoline, phthalazine, and benzothiazole reacted with gamma-lactams/amides to give the corresponding C(sp(2))-H amidoalkylation products in moderate to good yields with high regioselectivity. This visible-light-induced photocatalyst-free reaction was conducted in H2O at ambient temperature, which comply with the principles of green chemistry. The new K2S2O8 catalytic mechanism was investigated with control experiments.
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