Journal
DALTON TRANSACTIONS
Volume 50, Issue 31, Pages 10701-10706Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1dt00979f
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Funding
- Wellcome Trust (UK)
- University of Queensland (Australia)
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The introduction of a propyl-sulfonic acid group at N1 of the coordinated ligand gives rise to a water-soluble complex that can bind to lysozyme through non-covalent interactions. This complex shows selective moderate toxicity against Cryptococcus neoformans and exhibits no cytotoxicity to healthy HEK293 cells.
Introduction of the propyl-sulfonic acid group at N1 of the coordinated 2-(2-pyridyl)benzimidazole ligand (L) in [RhCl(eta(5)-C5Me5)L](CF3SO3) gives rise to a water-soluble complex, which can bind to the model protein lysozyme via non-covalent interactions. The complex shows selective moderate toxicity against Cryptococcus neoformans (MIC = 21.6-43.3 mu M) and exhibits no cytotoxicity to healthy HEK293 cells.
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