Journal
BMJ CASE REPORTS
Volume 14, Issue 7, Pages -Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/bcr-2020-236555
Keywords
vasculitis; acute renal failure; proteinurea; genetics; pathology
Categories
Ask authors/readers for more resources
This case study documents the coexistence of anti-GBM disease and IgA nephropathy, a phenomenon not well-documented in literature. The report also delves into the association of malignancy and glomerulonephritis, along with the role of genetics and human leukocyte antigen (HLA) typing in risk stratification.
A 66-year-old Asian woman presented with severe kidney injury, microscopic haematuria and subnephrotic range proteinuria with elevated serum anti-glomerular basement membrane (anti-GBM) titre. She had a history of renal cell carcinoma. Renal biopsy revealed dual pathology with immunofluorescence showing 3+ linear glomerular IgG staining and 3+ IgA mesangial staining. Cellular crescents were present on light microscopy and electron microscopy revealed increased mesangial matrix. She was treated with plasma exchange and immunosuppression and remained in stage 4 chronic kidney disease. This case describes the coexistence of anti-GBM disease and IgA nephropathy, a phenomenon not well described in the literature. The report also explores the association of malignancy and glomerulonephritis as well as the role of genetics and the utility of human leukocyte antigen (HLA) typing in risk stratification.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available