Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 68, Pages 8488-8491Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc03752h
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Funding
- [SERB/EMR/2017/003054]
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Polyanionic molybdate has been demonstrated to inhibit and degrade protein fibrils both in vitro and in vivo, showing potential therapeutic effects in the treatment of Alzheimer's disease.
The ability of polyanionic molybdate to inhibit and degrade protein fibrils both in vitro (insulin protein) and in vivo (Drosophila fly model) has been demonstrated. We establish the disappearance of fibrillar structures and recovery from neurodegenerative disorders in molybdate-treated A beta 42-mutant Drosophila flies as compared to the untreated ones, corroborating the therapeutic ability of ammonium molybdate towards the treatment of Alzheimer's disease.
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