Journal
CURRENT MEDICINAL CHEMISTRY
Volume 28, Issue 20, Pages 3964-3979Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867327666201027153123
Keywords
COVID-19; SARS-CoV-2; infection; coronavirus immune response; vaccine development; vaccine phases
Funding
- Spanish National Research Council (CSIC) [PIE CSIC-COV19-027]
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The article analyzes the immune response to SARS coronaviruses to predict the outcome of COVID-19 vaccines. Variations in immune response among different age groups were found, suggesting the need for vaccine designs considering these differences.
In December 2019, a novel respiratory coronavirus named SARS-CoV-2 appeared in China, causing the disease termed COVID-19 that has caused millions of infections worldwide. In this article, we have analyzed existing evidence on the immune response against SARS coronaviruses in order to understand the possible outcome of a vaccine for COVID-19. From our analysis, it becomes clear that there is a big difference in the immune response against SARS in children, young adults and the elderly, both at the innate and adaptive levels. Taking this information into account, we have studied the strategies that are being used for the development of COVID-19 vaccines. We discussed the perspectives for obtention and worldwide distribution of reliable vaccines using this perspective. The conclusion is that different vaccines may be protective for different age segments within the population, depending on the strategy used for their design. Therefore, it will become necessary for several vaccines to reach the finish line, not only to ensure availability, but also to guarantee an adequate immune response at the individual level.
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