Nanomaterial-based drug delivery systems as promising carriers for patients with COVID-19

Once the World Health Organization (WHO) declared the COVID-19 outbreak to be pandemic, massive efforts have been launched by researchers around the globe to combat this emerging infectious disease. Here we review the most recent data on the novel SARS-CoV-2 pathogen. We analyzed its etiology, pathogenesis, diagnosis, prevention, and current medications. After that, we summarized the promising drug delivery application of nanomaterial-based systems. Their preparation routes, unique advantages over the traditional drug delivery routes and their toxicity though risk analysis were also covered. We also discussed in detail the mechanism of action for one example of drug-loaded nanomaterial drug delivery systems (Avigan-contained nano-emulsions). This review provides insights about employing nanomaterial-based drug delivery systems for the treatment of COVID-19 to increase the bioavailability of current drugs, reducing their toxicity, and to increase their efficiency.

Automated summary

Researchers have launched massive efforts globally to combat the COVID-19 pandemic, reviewing data on the novel SARS-CoV-2 pathogen, analyzing its etiology, pathogenesis, diagnosis, prevention, and current medications. Nanomaterial-based drug delivery systems are promising for increasing drug bioavailability, reducing toxicity, and enhancing efficiency in treating COVID-19.