Circular RNAs Interaction with MiRNAs: Emerging Roles in Breast Cancer

Despite significant advances in cancer therapy strategies, breast cancer is one of the most common and lethal malignancies worldwide. Characterization of a new class of RNAs using next-generation sequencing opened new doors toward uncovering etiopathogenesis mechanisms of breast cancer as well as prognostic and diagnostic biomarkers. Circular RNAs (circRNAs) are a novel class of RNA with covalently closed and highly stable structures generated primarily from the back-splicing of precursor mRNAs. Although circRNAs exert their function through various mechanisms, acting as a sponge for miRNAs is their primary mechanism of function. Furthermore, growing evidence has shown that aberrant expression of circRNAs is involved in the various hallmarks of cancers. This paper reviews the biogenesis, characteristics, and mechanism of functions of circRNAs and their deregulation in various cancers. Finally, we focused on the circRNAs roles as a sponge for miRNAs in the development, metastasis, angiogenesis, drug resistance, apoptosis, and immune responses of breast cancer.

Automated summary

Despite significant advances in cancer therapy strategies, breast cancer remains one of the most common and lethal malignancies worldwide. The study of circRNAs, a novel class of highly stable RNAs, has shed light on their involvement in various hallmarks of cancers, particularly as sponges for miRNAs in breast cancer development, metastasis, angiogenesis, drug resistance, apoptosis, and immune responses.