A practical approach to normocalcemic primary hyperparathyroidism

Normocalcemic primary hyperparathyroidism is an entity on which several issues about its clinical management remains unclear. This is reflected in the main current guidelines, where there are no evidence-based specific recommendations. Through an exhaustive review of current literature, a clinical management algorithm for these patients is proposed. We consider the diagnosis criteria, the differential diagnosis, the clinical manifestations, and the treatment indications. When indicated, we also review the preoperative locations techniques and the surgical approach. Finally, when surgical treatment is not indicated, the patient is not a candidate to surgery or refuse surgical management, we review the medical treatment options and the follow-up schemes.

Automated summary

Normocalcemic primary hyperparathyroidism poses challenges in clinical management due to unclear guidelines with no evidence-based specific recommendations. A comprehensive approach is necessary, considering diagnosis, differential diagnosis, treatment indications, surgical options, and medical treatment for patients who are not candidates for surgery.